Table 3: Main results from the SPRINT study.

Variable

Intensive

treatment,

%

Standard

treatment,

%

Hazard

ratio

RRR,

%

p

RAR,

%

NNT

Primary outcome

5.2

6.8

0.75

25

< 0.001

1.6

62

Death from any cause

3.3

4.5

0.73

27

0.003

1.2

83

Death from CV cause

0.8

1.4

0.43

57

0.005

0.6

166

Heart failure

1.3

2.1

0.62

38

0.002

0.8

125

Primary outcome

or death

7.1

9

0.78

22

< 0.001

1.9

52

Complications

Intensive

treatment,

%

Standard

treatment,

%

Hazard

ratio

IRR,

%

p

IAR,

%

NNH

Hypotension

2.4

1.4

1.70

70

0.001

1

100

Acute kidney injury

4.4

2.6

1.69

69

0.001

1.8

55

Syncope

3.5

2.4

1.45

45

0.003

1.1

90

30% ↓ eGFR in

patients without CKD

3.8

1.1

3.45

345

0.001

2.7

37

RRR = reduction of relative risk.

RAR = reduction of absolute risk.

IRR = increment of relative risk.

IAR = increment of absolute risk.

NNT = number needed to treat.

NNH = number needed to harm.

Although consistent, there are small variations between these estimates and those provided by the authors in the original article.